Hearing impairment in leukemic patients is noted in many textbooks. Leukemic infiltrations and inner ear hemorrhage are known as its causes. As leukemia is a serious, sometimes fatal, disease and otolaryngologic complaints by leukemic patients are rare, clinicians usually neglect and pay little attention to them. The authors selected 22 patients among those who had been diagnosed as leukemia our hospital and did otolaryngologic, especially otologic, observation. So the authors obtained following results. 1) Among 22 patients, 20 are of myelocytic leukemia, half of the patients are at age of 20s and 30s and male vs. female ratio is 10 : 12. 2) Six cases of vertigo, 3 cases of tinnitus, 2 cases of ear fullness and 1 case of hearing loss are otologic complaints. Patients with otologic complaints are 8. 3) The most prevalent objective finding is 77 cases of hearing loss. The next is each 1 case of eardrum bulging and nystagmus. 4) Among 7 cases of hearing loss, perceptive type is 5, mixed type 2 and unilateral is 4, bilateral 3. 5) Eleven patients (half of the cases) reveal subjective and objective otologic symptoms and signs. 6) Hearing loss is thought to have no corresponding relationship with otologic symptoms and signs.