|
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1996;39(4): 561-7. |
Growth Stimulation of Cholestratoma Epithelium by Transforming Growth Factor-Alpha |
Geon-Tae Park, MD, Gwang-Hee Woo, MD, Jin-Hack Cho, MD, Chin-Saeng Cho, MD, and Kyung-You Park, MD |
Department of Otolaryngology, College of Medicine, Hallym University, Chunchon, Korea |
Transforming Growth Factor-Alpha에 의한 진주종 상피세포 성장촉진에 관한 연구 |
박건태 · 우광희 · 조진학 · 조진생 · 박경유 |
한림대학교 의과대학 이비인후과학교실 |
|
|
|
ABSTRACT |
The squamous epithelium invading the middle ear markedly alters its growth properties and cause a complex disease known as cholesteatoma. Unless surgically removed, the keratinizing epithelium can results in complication through bone destruction. Both the etiology and pathogenesis of cholesteatoma seem to be related to the epithelial cell migration, proliferation, and differentiation. But the destructive life threatening process is not understood. Thransforming growth factor alpha is known to be produced by normal keratinocyte and to acts on EGFR factor alpha is known to be produced by normal human keratinocyte and to acts on EGFR and to stimulate their proliferation. Authors observed the distribution pattern of EGFR and TGF-α in cholesteatoma and normal meatal skin after immunohistochemical stain. EGFR was highly expressed in the basal layer of the epodermis of normal meatal skin. In the majority of chlosteatoma, expression of EGFR was not not confined to the basal layer but persisted in suprabasal layer. TGF-α was consistently stronger in cholesteatoma than in normal meatal skin. For infiltration of immune cells, the stroma of cholesteatoma stained positively for TGF-α. These data may be consistent with autocrine stimulation of the squamous epithelium of cholesteatoma by TGF-α contributing to its unrestrained growth in the middle ear cavity.
|
Keywords:
Squamous epithelium of cholesteatomaㆍEGFRㆍTGF-αㆍAutocrine stimulation. |
|
|
|