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Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1995;38(3): 407-12. |
Immunohistochemical Study of p53 Expression in Head and Neck Squamous Cell Carcinoma |
Chung-Hwan Baek, MD1, Kyung-Ho Yoo, MD1, Cheol-Hwe Jeong, MD1, Mee-Sook Roh, MD2, and Sook-Hee Hong, MD2 |
1;Department of Otolaryngology-Head and Neck Surgery, 2;Pathology, College of Medicine Dong-A University, Pusan, Korea |
두경부 편평상피암에서 p53의 표현양상에 관한 면역조직화학적 연구 |
백정환1 · 유경호1 · 정철회1 · 노미숙2 · 홍숙희2 |
동아대학교 의과대학 이비인후과학교실1;병리학교실2; |
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ABSTRACT |
Mutation and/or deletion of p53 tumor suppressor gene is one of the most common genetic abnormalities in diverse human cancers. The wild-type p53 gene participates in suppressing cell transformation while the mutant forms have tumorigenic potential. The wild-type p53 with a relatiely short half-life is found in all normal cell types with very low concentration and is undetectable by standard immunohistochemical staining. The mutant-forms with their prolonged half-life accumulate to much higher concentatrations in cells and can be detected by immunohisochemical staining. We evaluated p53 expression by immunohisochemical staining with anti-p53 monoclonal antibody. DO-1(Oncogene Science, Uniondale, NY) in 48 paraffin-embedded tissues of head and neck squamous cell carcinomas and investigated the relationship between p53 expression and clinicopathological status. Eighteen(38%) out of 48 cases showed p53 hyperexpression, however there was no singificant correlation between p53 expression and clinicopathological parameters such as tumor staging lymph node status, and tumor differentiation grade.
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Keywords:
p53ㆍHead and neck squamous cell carcinomasㆍImmunohisochemical staining. |
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