A variety of adjuvant chemotherapy programs have been used to try and improve the effectiveness of local treatment such as surgery and radiation therapy for squamous cell carcinoma of the head and neck. A clinical study was done using statistical analysis to investigate the effectiveness and feasibility of induction chemotherapy with cis-platinum, vinblastin and 5 -fluorouracil. Forty-three patients who were diagnosed pathologically as squamous cell carcinoma of the head and neck from Mar. 1984 to Feb. 1986 were evaluated. The results were as followed : 1) Among a total of 43 cases, 27 cases(74.4%) showed objective remission and there were 5 cases of complete remission and 22 cases of partial remission. 2) Remission rates related to various primary tumor sites revealed that the oral cavity(85.7%) had the highest remission rate followed by the larynx, the oropharynx, the hypopharynx and the nasopharynx. 3) Remissions were not significantly influenced by primary tumor status, nodal status and the degree of differentiation of tumor cells. 4) During or after local treatment, there were no significant disturbance related to induction chemotherapy. 5) For patient who showed objective remission to induction chemotherapy, there was a need for adequate explanation of the significance of local treatment. 6) Long-term follow-up was suggested so that the relationship could be determined between the survival rate and remission rate to induction chemotherapy, and the survival rate and the status of the disease. 7) Induction chemotherapy produced only mild toxic reactions such as nausea, vomiting, diarrhea and mucositis. These reactions were easily controlled.