Nasal packing is essential treatment tool for epistaxis or post-operative nasal bleeding. Its complications are divided into general and local ones. Local complications are inflammatory changes in the nasal mucosa, such as proliferation of epithelial cells, Goblet cells and capillaries and infiltration of inflammatory cells. The longer the packing period, the higher the risk of these complications. On the other hand, there has been few pathologic studies of local changes in the nasal mucosa after nasal packing which has been used so frequently in ENT. We studied the local changes in nasal mucosa, which was undertaken in 5 groups of experimental animals after the nasal packing using various materials and systemic antibiotics therapy. The results obtained were as follows ; 1) The proliferation of epithelial cells, Goblet cells and capillaries and infiltration of inflammatory cells were noted in all 5 groups. 2) The degree of local inflammatory changes in the nasal mucosa was delayed or diminished in the group which received systemic antibiotics therapy. 3) In case with packing for 10 days, the degree of inflammatory reaction was similar in both experimental groups regardless of the route and performance of antibiotics therapy and tissue damage such as epithelial desquamation became more severe. 4) In animals with packing for more than 7 days, the recovery changes of the nasal mucosa were very similar in both groups regardless of the performance of antibiotics therapy. Also submucosal fibrosis was noted on the tenth day after removal of the nasal packing. With the above results, a period of packing of less than 5 days may be an effective factor in decreasing nasal mucosal damage and inflammatory reaction. The use of local antibiotics and systemic antibiotics therapy before and after packing is another factor in decreasing mucosal change and rapid recovery of damaged mucosa.