Melanoma is a malignant neoplasm arising from melanocyte and has been considered a rare tumor with an unpredictable behavior that varies from spontaneous regression to rapid progression and death. Melanoma can arise in almost any location-skin, eye, and mucosa of the repiratory, alimentary and urogenital tracts. Usually surgical excision is the preferred treatment. However, surgical therapy must be guided by the general principle of surgical oncology for the particular anatomic site. When primary site of melanoma is of mucosal origin, treatment of primary lesion is often hampered by anatomic retrictions and large size, which results from the delayed diagnosis caused by their location. Besides surgical excision, radiation therapy and immunotherapy with B.C.G. or D.N.C.B. is also recommended. After the disease is disseminated, treatment is more complicated.